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ڴ ȭаа ġ 1970 9 ̱ ۵ п лȰ ߴ. ڻ ߴ оߴ ÿ ۵ƴ ' (biomedical engineering)' ε ߷» ϴ , ش о߿ üῡ ڻ Ҵ.
1976 ѱб(ī̽Ʈ) ߴµ ̱ оߴ ʾ ' '̶ о߸ ϱ ߴ.
оߴ 1970 Ĺݺ ȭڵ ũ ̷ о߿. ȭϱⰡ ʴٴ , п а õ ο оߵ ܳ鼭 κ ⸦ ϱ Ͼ. Ȧ ܷӰ 30 о̱ ϴ. ȿ '(fed-batch)' ڰ 10 ̻ 꼺 ٴܰ (MSC-HCDC, Multi-stage continuous high cell density culture) ü , ̰ ڰ о Ʈ ô Ѿ ߸ شѴٰ ںϰ ִ.
ϸ ̿ Ḧ Ĺ ٲٰ, ̿ϴ ü ִ. ̻ Ḧ 翡 ٲٴ 20谡 꼺 ϴ. ̷ ̿ 10 7~7.3 ⸧(10.4), (9.3), (8.5) ǰ ִ.
ֱ ߱ ¡ ȸ ǥߴµ þҴ ȭб '' ΰֵ ڻ װ ̿ ȭ ȸ ð ־, " ̿ ȭ ȯ ְڴ" ϱ ߴ.
ó о ڷμ ڸ 쿩 ־ ƽþ ü(AFOB) ȸ ô ڷμ о 鿡 ־ о߿ ̶ Ѵ. 320 , 6 ο Ƚ 9159ȸ ȭа о߿ ̶ װ Ҽ . ġٵ ϴٰ Ǯ Ǯ ڱġ ִ. Ը ϼǰ ̿ ڵ Ǵ .
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